公海彩船: 课题组长
姓名:
郑辉助理教授 研究员 博士生导师, PhD, 助理教授
职务:
所在院所:
公海彩船
荣誉称号:
教育经历:
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2007/09—2012/07,华中科技大学,学士
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2012/09—2017/07,清华大学,博士
博士后及工作经历:
- 2017/07—2019/07,清华大学,生命科学公海彩船,博士后
- 2019/07—2020/12,武汉菲沙基因信息有限公司,研发中心,首席科学家
- 2021/04—至今,上海科技大学,公海彩船,助理教授(TENURE-TRACK)
公海彩船: 课题组简介
研究方向:
染色质与表观基因组学,表观遗传信息的跨代遗传
研究内容:
结合分子生物学、基因组学、发育生物学和生物信息学等手段,采用干湿实验结合的方式,研究动物配子发育、早期胚胎发育及分化、以及人类疾病中表观遗传调控的机制。课题组目前的主要研究方向:(1)动物配子发育过程中的表观基因组调控;(2)表观基因组编辑技术的优化与应用;(3)哺乳动物表观遗传信息跨代遗传的分子机制。
公海彩船: 代表性论文(*第一作者,#通讯作者)
- 1. Zhang, Ke*; Wu, Dan-Ya*; Zheng, Hui*; Wang, Yao*; Sun, Qiao-Ran; Liu, Xin; Wang, Li-Yan; Xiong, Wen-Jing; Wang, Qiujun; Rhodes, James D.P.; Xu, Kai; Li, Lijia; Lin, Zili; Yu, Guang; Xia, Weikun; Huang, Bo; Du, Zhenhai; Yao, Yao; Nasmyth, Kim A.; Klose, Robert J.; Miao, Yi-Liang#; Xie, Wei#.Analysis of genome architecture during SCNT reveals a role of cohesin in impeding minor ZGA.MOLECULAR CELL. Jul 2020.
- 2. Du, Zhenhai*; Zheng, Hui*; Kawamura, Yumiko K.*; Zhang, Ke*; Gassler, Johanna; Powell, Sean; Xu, Qianhua; Lin, Zili; Xu, Kai; Zhou, Qian; Ozonov, Evgeniy A.; Ve ? ron, Nathalie; Huang, Bo; Li, Lijia; Yu, Guang; Liu, Ling; Yeung, Wan Kin Au; Wang, Peizhe; Chang, Lei; Wang, Qiujun; He, Aibin; Sun, Yujie; Na, Jie; Sun, Qingyuan; Sasaki, Hiroyuki; Tachibana, Kikue; Peters, Antoine H.F.M.#; Xie, Wei#.Polycomb group proteins regulate chromatin architecture in mouse oocytes and early embryos.MOLECULAR CELL. Feb 2020.
- 3. Zheng, Hui*; Xie, Wei#.The role of 3D genome organization in development and cell differentiation.NATURE REVIEWS MOLECULAR CELL BIOLOGY. Sep 2019.
- 4. Li, Yuanyuan*; Zheng, Hui*; Wang, Qiujun; Zhou, Chen; Wei, Lei; Liu, Xuehui; Zhang, Wenhao; Zhang, Yu; Du, Zhenhai; Wang, Xiaowo; Xie, Wei#.Genomewide analyses reveal a role of Polycomb in promoting hypomethylation of DNA methylation valley.GENOME BIOLOGY. Feb 2018.
- 5. Du, Zhenhai*; Zheng, Hui; Huang, Bo; Ma, Rui; Wu, Jingyi; Zhang, Xianglin; He, Jing; Xiang, Yunlong; Wang, Qiujun; Li, Yuanyuan; Ma, Jing; Zhang, Xu; Zhang, Ke; Wang, Yang; Zhang, Michael Q; Gao, Juntao; Dixon, Jesse R; Wang, Xiaowo; Zeng, Jianyang; Xie, Wei#.Allelic reprogramming of 3D chromatin architecture during early mammalian development.NATURE. Jul 2017.
- 6. Zhang, Bingjie*; Zheng, Hui*; Huang, Bo*; Li, Wenzhi*; Xiang, Yunlong; Peng, Xu; Ming, Jia; Wu, Xiaotong; Zhang, Yu; Xu, Qianhua; Liu, Wenqiang; Kou, Xiaochen; Zhao, Yanhong; He, Wenteng; Li, Chong; Chen, Bo; Li, Yuanyuan; Wang, Qiujun; Ma, jing; Yin, Qiangzong; Kee, Kehkooi; Meng, Anming; Gao, Shaorong; Xu, Feng; Na, Jie#; Xie, Wei#.Allelic reprogramming of the histone modification H3K4me3 in early mammalian development.NATURE. Sep 2016.
- 7. Zheng, Hui*; Huang, Bo*; Zhang, Bingjie*; Xiang, Yunlong; Du, Zhenhai; Xu, Qianhua; Li, Yuanyuan; Wang, Qiujun; Ma, Jing; Peng, Xu; Xu, Feng; Xie, Wei#.Resetting epigenetic memory by reprogramming of histone modifications in mammals.MOLECULAR CELL. Sep 2016.
- 8. Wu, Jingyi*; Huang, Bo*; Chen, He; Yin, Qiangzong; Liu, Yang; Xiang, Yunlong; Zhang, Bingjie; Liu, Bofeng; Wang, Qiujun; Xia, Weikun; Li, Wenzhi; Li, Yuanyuan; Ma, Jing; Peng, Xu; Zheng, Hui; Ming, Jia; Zhang, Wenhao; Zhang, Jing; Tian, Geng; Xu, Feng; Chang, Zai; Na, Jie; Yang, Xuerui; Xie, Wei#.The landscape of accessible chromatin in mammalian preimplantation embryos.NATURE. Jun 2016.
公海彩船: 课题组成员及合影
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姓名:瞿诗媛
身份:博士研究生
在组时间:2021/9-至今
邮箱:qushy@shanghaitech.edu.cn
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姓名:邓欢欢
身份:硕士研究生
在组时间:2022/1-至今
邮箱:denghh1@shanghaitech.edu.cn
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姓名:苏炼
身份:硕士研究生
在组时间:2022/1-至今
邮箱:sulian@shanghaitech.edu.cn
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姓名:田露
身份:硕士研究生
在组时间:2022/1-至今
邮箱:tianlu@shanghaitech.edu.cn
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